June 26, 2017

Prenatal Fish Oil – Lower Risk of Asthma in Children

Prenatal Fish Oil Supplementation May Lower Risk of Asthma in Children

Taking fish oil supplements during pregnancy may lower the risk of asthma in children, according to a new study published in the New England Journal of Medicine.

The study shows that supplementation with long-chain polyunsaturated fatty acids (LCPUFA) during the third trimester can reduce the risk of asthma or persistent wheeze in the babies. LCPUFA supplementation also reduces the risk of lower respiratory tract infections (LRTIs) in the offspring.

Pregnant woman

Asthma in Children is a Significant Problem

Asthma is a common problem in children born in the United States. Approximately 7.4 percent of adults and 8.6 percent of children in the nation have asthma, according to the Asthma and Allergy Foundation of America (AAFA), and the number of children with the breathing disorder has been increasing since the 1980s.

Hospitalization rates for asthma are historically higher in the Northeast. Massachusetts has the highest prevalence rate for asthma at 12 percent, according to statistics presented by the Centers for Disease Control and Prevention (CDC), with several other northeastern states following with asthma prevalence rates topping 10 percent.

Fish Oil-Derived LCPUFAs in Pregnancy and Asthma in Offspring

Reduced intake of LCPUFAs may contribute to the increased incidence of wheezing and asthma in children. The researchers in the NEJM study hoped to evaluate the effects of maternal LCPUFA supplementation on offspring.

The scientists enrolled 736 pregnant women at 24 weeks of gestation into the study then randomly assigned the subjects to control and test Asthma-prenatal-fish-oil-frank-magliochetti-report-healthcaregroups. Participants in the test group received 2.4 g of n−3 LCPUFA derived from fish oil each day, while those in the control group took a placebo containing olive oil daily.

The participants’ offspring became the Copenhagen Prospective Studies on Asthma in Childhood (COPSAC) cohort. The researchers followed this group of children for several years, with pediatricians collecting clinical data for visits at 1 week after birth, and then at 1, 3, 6 months and every 6 months until the children reached 36 months of age. The pediatricians then saw the children yearly until the participants were 5 years old.

Neither the researchers nor the participants knew which group the children belonged to for the first three years of follow-up studies. During the next two years of follow-up studies, only the scientists were unaware of the group assignments.

The researchers looked primarily for persistent wheezing and asthma, but included LRTIs, eczema, asthma exacerbations, and allergic sensitization as secondary endpoints.

Ninety-five percent of the 695 children included in the COPSAC cohort completed the 3-year, double-blind follow-up portion of the study. The researchers found that the risk of asthma or persistent wheeze in the treatment group receiving LCPUFA was 16.9 percent, while the risk was 23.7 percent in the control group. This means consuming fish oil-derived LCPUFAs can lower the risk of persistent wheeze or asthma and LRTIs in offspring by nearly 7 percentage points, or one-third. Analysis of the secondary endpoints showed that supplementation reduces the risk of LRTIs, but there was no association between supplementation and asthma exacerbations, allergic sensitization, or eczema.

These findings would be extremely helpful for expectant mothers hoping to reduce the risk of asthma and other breathing problems in their children.

Source

http://www.nejm.org/doi/full/10.1056/NEJMoa1503734

http://www.aafa.org/page/asthma-facts.aspx

https://www.ncbi.nlm.nih.gov/pubmed/12214899

https://www.cdc.gov/asthma/most_recent_data_states.htm

Frank Magliochetti is Managing Partner for Parcae Capital

  • North Andover, Massachusetts

This column of posts is directed at the Healthcare Industry.  Frank plans to release new sites dedicated to the industry. Frank currently assists companies who are building, restructuring, transforming and resurrecting there business’s. An example of his client base are, Xenetic Biosciences , IPC Medical Corp, Just Fellowship Corp, Environmental Services Inc., Parsons Post House LLC, ClickStream Corporation as well as having a business talk radio show; The Business Architect on the URBN network.

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Is a site sponsored and driven by content supplied and aggregated  by Frank Magliochetti and Parcae Capital Corporation.  It will highlight emerging growth companies and picks made by Frank Magliochetti and his team of professionals.

Here are some of the Companies featured on the site:

OPKO Health, Inc

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Pharmasynthez

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About

Frank Magliochetti

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Here is a brief summary bio of Frank Magliochetti’s history:

was born September 13, 1957 in Malden, Massachusetts. He attended Malden Catholic High School and was a four letter athlete for the school. After high-school he obtained a B.S. in Pharmacy from Northeastern University and played Baseball and football. He stayed at Northeastern and entered the Masters of Toxicology program. Where he worked on the effects of Valium and its metabolism while taking Tagamet for the condition of anxiety induced ulcers. He later received his MBA from The Sawyer School of Business at Suffolk University specializing in corporate finance, completed the Advanced Management Program at Harvard Business School and the General Management Program at Stanford Business School. Frank started a chain of independent pharmacies shortly out of school and eventually sold it. He worked in various positions throughout the American Hospital Supply and later the Baxter International organization prior to leaving he was part of the senior management team for the Neuro-surgical business unit.

Frank spent a period of time as an investment banker prior to becoming the President of Kontron Instruments a maker of a class 3 medical device; an Intra-Aortic Balloon and console. He worked with the Food & Drug administration in developing internal policies and practices which would eventually lead to the removing of the consent decree which was placed on the company for poor manufacturing practices prior to his involvement. He returned the company to profitability after a long period of losses. Kontron was eventually sold to a prominent medical device company. As Senior Vice President of North America for Haemonetics Corporation, Frank managed the day to day activities for the North America business activities. During his tenure sales and profits grew double digits for 13 consecutive quarters and the stock of the Company doubled and forward split and grew 40% before he left to run Sandoz Pharma North American Operations. Sandoz eventually merged with Ciba becoming one of the largest Pharma companies in the world, Novartis.

Frank then went on to create one of the largest infusion therapy and medicare nursing companies in the world, employing more than 40,000 employees. Over a three year period he saw his stock appreciate 10 fold. He then created several orthopedic product and services entities. One of which, Orthorehab, was sold for 52 times its original investment just 30 months after starting it for 52 million dollars.

He currently assists companies who are building, restructuring, transforming and resurrecting there business’s. An example of his client base are, Xenetic Biosciences , IPC Medical Corp, Just Fellowship Corp, Environmental Services Inc., Parsons Post House LLC, ClickStream Corporation as well as having a business talk radio show; The Business Architect on the URBN network.

Frank is now Managing Partner of North Andover, MA based Parcae Capital.

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Frank Magliochetti Current Works-

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Parcae Capital offers personalized investment banking services for emerging growth companies. We specialize in finding companies which have leading edge technology, services or intellectual property in the healthcare, media and alternative energy space. We assist both public and private companies in preparing to raise private and public capital for all phases of growth. Parcae Capital also offers comprehensive assistance in mergers, acquisitions and related services. Our work out group specializes in business restructuring and recapitalization.

Absolute Day Trader Picks

Day Trader Picks

Is a site sponsored and driven by content supplied by North Andover Businessman Frank Magliochetti and Parcae Capital Corporation.  Absolute Day Trader will highlight emerging growth companies and picks made by Frank Magliochetti and his team of professionals.

If you have a company interested in having our team review for our Absolute Day Trading Pick please contact us by clicking here.

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